Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response

Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response

Abstract Toll-like receptor 19 (Tlr19) is a fish-specific TLR that plays a critical role in innate immunity. In the present study, we aimed to identify tlr19 from common carp (Cyprinus carpio L.) and explored its expression profile, localization, adaptor, and signaling pathways. A novel tlr19 cDNA s...

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Bibliographic Details
Main Authors: Shijuan Shan, Rongrong Liu, Hanxiao Feng, Fei Meng, Muhanmmad Aizaz, Guiwen Yang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Veterinary Research
Subjects:
Cyprinus carpio L.
Toll-like receptor 19 (Tlr19)
Innate immunity
Signaling pathway
Ifn
Online Access:https://doi.org/10.1186/s13567-021-00957-3

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