Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation

Summary: Chimeric mice have been generated by injecting pluripotent stem cells into morula-to-blastocyst stage mouse embryo or by introducing more mature cells into later stage embryos that correspond to the differentiation stage of the donor cells. It has not been rigorously tested, however, whethe...

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Bibliographic Details
Main Authors: Malkiel A. Cohen, Styliani Markoulaki, Rudolf Jaenisch
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118301103