CYP2A6 gene polymorphisms impact to nicotine metabolism

CYP2A6 gene polymorphisms impact to nicotine metabolism

<p>Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nico...

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Bibliographic Details
Main Authors:	Dewi Muliaty, Irawan Yusuf, Rianto Setiabudy, Septelia I. Wanandi
Format:	Article
Language:	English
Published:	Faculty of Medicine Universitas Indonesia 2010-02-01
Series:	Medical Journal of Indonesia
Online Access:	http://mji.ui.ac.id/journal/index.php/mji/article/view/377

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