Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.

Bibliographic Details
Main Authors: Kamil Sołtysik, Yuki Ohsaki, Tsuyako Tatematsu, Jinglei Cheng, Toyoshi Fujimoto
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08411-x
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spelling doaj-98f83579d492448e8f406580e20eef6d2021-05-11T11:37:48ZengNature Publishing GroupNature Communications2041-17232019-01-0110111210.1038/s41467-019-08411-xNuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesisKamil Sołtysik0Yuki Ohsaki1Tsuyako Tatematsu2Jinglei Cheng3Toyoshi Fujimoto4Department of Molecular Cell Biology and Anatomy, Nagoya University Graduate School of MedicineDepartment of Molecular Cell Biology and Anatomy, Nagoya University Graduate School of MedicineDepartment of Molecular Cell Biology and Anatomy, Nagoya University Graduate School of MedicineDepartment of Molecular Cell Biology and Anatomy, Nagoya University Graduate School of MedicineDepartment of Molecular Cell Biology and Anatomy, Nagoya University Graduate School of MedicineThe origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.https://doi.org/10.1038/s41467-019-08411-x
collection DOAJ
language English
format Article
sources DOAJ
author Kamil Sołtysik
Yuki Ohsaki
Tsuyako Tatematsu
Jinglei Cheng
Toyoshi Fujimoto
spellingShingle Kamil Sołtysik
Yuki Ohsaki
Tsuyako Tatematsu
Jinglei Cheng
Toyoshi Fujimoto
Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
Nature Communications
author_facet Kamil Sołtysik
Yuki Ohsaki
Tsuyako Tatematsu
Jinglei Cheng
Toyoshi Fujimoto
author_sort Kamil Sołtysik
title Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_short Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_full Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_fullStr Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_full_unstemmed Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_sort nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-01-01
description The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.
url https://doi.org/10.1038/s41467-019-08411-x
work_keys_str_mv AT kamilsołtysik nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
AT yukiohsaki nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
AT tsuyakotatematsu nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
AT jingleicheng nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
AT toyoshifujimoto nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
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