Investigation of the Inhibitory Effects of the Benzodiazepine Derivative, 5-BDBD on P2X4 Purinergic Receptors by two Complementary Methods

Background/Aims: ATP-gated P2X4 purinergic receptors (P2X4Rs) are cation channels with important roles in diverse cell types. To date, lack of specific inhibitors has hampered investigations on P2X4Rs. Recently, the benzodiazepine derivative, 5-BDBD has been proposed to selectively inhibit P2X4Rs. H...

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Bibliographic Details
Main Authors: Bernadett Balázs, Tamás Dankó, Gergely Kovács, László Köles, Matthias A. Hediger, Ákos Zsembery
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
ATP
Online Access:http://www.karger.com/Article/FullText/350119

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