NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone

Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA)...

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Bibliographic Details
Main Authors: Ryan E. Tomlinson, Zhi Li, Qian Zhang, Brian C. Goh, Zhu Li, Daniel L.J. Thorek, Labchan Rajbhandari, Thomas M. Brushart, Liliana Minichiello, Fengquan Zhou, Arun Venkatesan, Thomas L. Clemens
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
sensory nerves
endochondral bone
nerve growth factor
neurotrophic tyrosine kinase receptor type 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310348

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