Metabolic Derangements in Patients of Psoriasis and their Association with Psoriasis Area Severity Index Score: A Cross-sectional Study

• Main Authors: Seema Goel, Shalini Bansal, Dimple Chopra, Jayati Batra
• Format: Article
• Language: English
• Published: JCDR Research and Publications Pvt. Ltd. 2021-04-01
• Series: National Journal of Laboratory Medicine
• Subjects: c-reactive protein; fasting blood sugar; lipid profile; uric acid
• Online Access: http://www.njlm.net/articles/PDF/2471/47050_CE[Ra]_F(Sh)_PF1(ShG_SHU)_PFA(SHU)_PN(SHU).pdf

Introduction: Psoriasis is a chronic inflammatory disease of skin associated with various metabolic derangements. These metabolic derangements increases the risk of cardiovascular diseases in psoriatic patients. Aim: To study the metabolic parameters- Fasting Blood Glucose (FBS), serum lipid profile, serum uric acid, C-Reactive Protein (CRP) in psoriatic patients in relation to clinical disease severityPsoriasis Area Severity Index (PASI) score. Materials and Methods: The study was a hospital based cross-sectional observational study carried out over a period of 18 months in Department of Dermatology at Government Medical College and Rajindra Hospital, Patiala that included 250 psoriatic patients. Their percentage Body Surface Area (BSA) involved and PASI score were calculated as per the standard guidelines. The severity of psoriasis was divided into mild (PASI<7), moderate (PASI 7-12) and severe (PASI >12) disease based on PASI score. Serum lipid profile was measured by enzymatic method, blood glucose by glucose oxidase method, serum uric acid by uricase method and CRP by latex slide agglutination method and the values obtained were compared with severity of psoriasis. Results: There was a rise in the value of FBS, serum lipid profile, serum uric acid and CRP as PASI score increased and the difference between these values was statistically highly significant (p-value <0.001). Conclusion: There was a significantly higher derangement of metabolic parameters in patients with higher PASI scores. So, patients with severe psoriasis have a higher risk of metabolic complications and cardiovascular diseases as compared to patients with mild disease. These patients should be advised lifestyle modifications and should be regularly monitored so that the metabolic derangements can be detected earlier and metabolic complications can be avoided.