Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis

Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis

The small interfering RNA (siRNA) is suggested to offer a novel means of treating atopic dermatitis (AD) because it allows the specific silencing of genes related to AD pathogenesis. In our previous study, we found that siRNA targeted against RelA, an important nuclear factor-kappa B (NF-κB) subdoma...

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Bibliographic Details
Main Authors: Takanori Kanazawa, Yuki Shizawa, Mayu Takeuchi, Kuniko Tamano, Hisako Ibaraki, Yasuo Seta, Yuki Takashima, Hiroaki Okada
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:Pharmaceutics
Subjects:
atopic dermatitis
skin topical application
siRNAs
NF-κB
sericin
hydrogel
Online Access:http://www.mdpi.com/1999-4923/7/3/294

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