Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells

Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells

The carcinogenesis and development of prostate cancer are mediated by enhanced Ca2+ signaling. In the present study, the pharmacological profile of the Ca2+-sensing receptor (CaSR) antagonists (calcilytics) was examined in human prostate cancer PC-3 cells. NPS2143 and Calhex 231 blocked extracellula...

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Main Authors: Aya Yamamura, Md Junayed Nayeem, Motohiko Sato
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319300131
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spelling doaj-98b164a323c64cf39919b8dda4566a002020-11-25T00:44:51ZengElsevierJournal of Pharmacological Sciences1347-86132019-03-011393254257Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cellsAya Yamamura0Md Junayed Nayeem1Motohiko Sato2Corresponding author. Fax: +81 561 63 9809.; Department of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, JapanDepartment of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, JapanDepartment of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, JapanThe carcinogenesis and development of prostate cancer are mediated by enhanced Ca2+ signaling. In the present study, the pharmacological profile of the Ca2+-sensing receptor (CaSR) antagonists (calcilytics) was examined in human prostate cancer PC-3 cells. NPS2143 and Calhex 231 blocked extracellular Ca2+-induced increases in cytosolic [Ca2+]. NPS2143 and Calhex 231 inhibited cell proliferation (IC50 = 7.4 and 10.3 μM, respectively) and migration. The exposure to NPS2143 or Calhex 231 down-regulated CaSR protein expression. These results demonstrated that calcilytics inhibited cell proliferation/migration and down-regulated CaSR expression in human prostate cancer cells, suggesting their potential as novel therapeutic drugs for prostate cancer. Keywords: Calcium-sensing receptor, Calcilytic, Prostate cancerhttp://www.sciencedirect.com/science/article/pii/S1347861319300131
collection DOAJ
language English
format Article
sources DOAJ
author Aya Yamamura
Md Junayed Nayeem
Motohiko Sato
spellingShingle Aya Yamamura
Md Junayed Nayeem
Motohiko Sato
Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
Journal of Pharmacological Sciences
author_facet Aya Yamamura
Md Junayed Nayeem
Motohiko Sato
author_sort Aya Yamamura
title Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
title_short Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
title_full Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
title_fullStr Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
title_full_unstemmed Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells
title_sort calcilytics inhibit the proliferation and migration of human prostate cancer pc-3 cells
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2019-03-01
description The carcinogenesis and development of prostate cancer are mediated by enhanced Ca2+ signaling. In the present study, the pharmacological profile of the Ca2+-sensing receptor (CaSR) antagonists (calcilytics) was examined in human prostate cancer PC-3 cells. NPS2143 and Calhex 231 blocked extracellular Ca2+-induced increases in cytosolic [Ca2+]. NPS2143 and Calhex 231 inhibited cell proliferation (IC50 = 7.4 and 10.3 μM, respectively) and migration. The exposure to NPS2143 or Calhex 231 down-regulated CaSR protein expression. These results demonstrated that calcilytics inhibited cell proliferation/migration and down-regulated CaSR expression in human prostate cancer cells, suggesting their potential as novel therapeutic drugs for prostate cancer. Keywords: Calcium-sensing receptor, Calcilytic, Prostate cancer
url http://www.sciencedirect.com/science/article/pii/S1347861319300131
work_keys_str_mv AT ayayamamura calcilyticsinhibittheproliferationandmigrationofhumanprostatecancerpc3cells
AT mdjunayednayeem calcilyticsinhibittheproliferationandmigrationofhumanprostatecancerpc3cells
AT motohikosato calcilyticsinhibittheproliferationandmigrationofhumanprostatecancerpc3cells
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