Parkinsonism secondary to metastatic lesions within the central nervous system: a case report

<p>Abstract</p> <p>Introduction</p> <p>Colorectal cancer is one of the most common human diseases worldwide, and metastases are detected in approximately 20% of patients at diagnosis. Brain metastases occur in only 4% of cases, however, and usually present with hemipare...

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Main Authors: Diezhandino Patricia, Cebayos Amelia, Uña Esther, Perea Christian, Hortelano Eduardo, González Montserrat
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Journal of Medical Case Reports
Online Access:http://www.jmedicalcasereports.com/content/4/1/218
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spelling doaj-98ae9282a800462d9e7191d1052d10ed2020-11-25T00:18:55ZengBMCJournal of Medical Case Reports1752-19472010-07-014121810.1186/1752-1947-4-218Parkinsonism secondary to metastatic lesions within the central nervous system: a case reportDiezhandino PatriciaCebayos AmeliaUña EstherPerea ChristianHortelano EduardoGonzález Montserrat<p>Abstract</p> <p>Introduction</p> <p>Colorectal cancer is one of the most common human diseases worldwide, and metastases are detected in approximately 20% of patients at diagnosis. Brain metastases occur in only 4% of cases, however, and usually present with hemiparesis or other motor or sensory symptoms. There have been only a few reports of parkinsonism secondary to a brain tumor-related mass effect.</p> <p>Case presentation</p> <p>We present an unusual case of parkinsonism secondary to multiple brain metastases. A 57-year-old Caucasian man had recently been diagnosed with primary carcinoma of the colon and had multiple metastases in the lungs and liver. He subsequently developed bilateral symmetrical parkinsonism, and multiple brain tumors were detected by computed tomography scanning. The condition of our patient deteriorated rapidly, and he became akinetic and dependent for all activities of daily living. He was followed up and treated at home by our palliative care unit team and died two weeks after the onset of his neurologic symptoms.</p> <p>Conclusion</p> <p>Although primary and secondary brain tumors are uncommon causes of parkinsonism, their clinical presentation may resemble that of idiopathic Parkinson's disease. An awareness of this rare differential diagnosis is therefore important in ensuring early diagnosis and treatment, thus improving prognosis and quality of life. A rapid progression in neurologic symptoms was observed in our patient, and clinicians should be alert to this atypical presentation of secondary parkinsonism.</p> http://www.jmedicalcasereports.com/content/4/1/218
collection DOAJ
language English
format Article
sources DOAJ
author Diezhandino Patricia
Cebayos Amelia
Uña Esther
Perea Christian
Hortelano Eduardo
González Montserrat
spellingShingle Diezhandino Patricia
Cebayos Amelia
Uña Esther
Perea Christian
Hortelano Eduardo
González Montserrat
Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
Journal of Medical Case Reports
author_facet Diezhandino Patricia
Cebayos Amelia
Uña Esther
Perea Christian
Hortelano Eduardo
González Montserrat
author_sort Diezhandino Patricia
title Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
title_short Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
title_full Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
title_fullStr Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
title_full_unstemmed Parkinsonism secondary to metastatic lesions within the central nervous system: a case report
title_sort parkinsonism secondary to metastatic lesions within the central nervous system: a case report
publisher BMC
series Journal of Medical Case Reports
issn 1752-1947
publishDate 2010-07-01
description <p>Abstract</p> <p>Introduction</p> <p>Colorectal cancer is one of the most common human diseases worldwide, and metastases are detected in approximately 20% of patients at diagnosis. Brain metastases occur in only 4% of cases, however, and usually present with hemiparesis or other motor or sensory symptoms. There have been only a few reports of parkinsonism secondary to a brain tumor-related mass effect.</p> <p>Case presentation</p> <p>We present an unusual case of parkinsonism secondary to multiple brain metastases. A 57-year-old Caucasian man had recently been diagnosed with primary carcinoma of the colon and had multiple metastases in the lungs and liver. He subsequently developed bilateral symmetrical parkinsonism, and multiple brain tumors were detected by computed tomography scanning. The condition of our patient deteriorated rapidly, and he became akinetic and dependent for all activities of daily living. He was followed up and treated at home by our palliative care unit team and died two weeks after the onset of his neurologic symptoms.</p> <p>Conclusion</p> <p>Although primary and secondary brain tumors are uncommon causes of parkinsonism, their clinical presentation may resemble that of idiopathic Parkinson's disease. An awareness of this rare differential diagnosis is therefore important in ensuring early diagnosis and treatment, thus improving prognosis and quality of life. A rapid progression in neurologic symptoms was observed in our patient, and clinicians should be alert to this atypical presentation of secondary parkinsonism.</p>
url http://www.jmedicalcasereports.com/content/4/1/218
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