Time-Resolved Monitoring of the Oxygen Transfer Rate of Chinese Hamster Ovary Cells Provides Insights Into Culture Behavior in Shake Flasks

Time-Resolved Monitoring of the Oxygen Transfer Rate of Chinese Hamster Ovary Cells Provides Insights Into Culture Behavior in Shake Flasks

Cultivations of mammalian cells are routinely conducted in shake flasks. In contrast to instrumented bioreactors, reliable options for non-invasive, time-resolved monitoring of the culture status in shake flasks are lacking. The Respiration Activity Monitoring Respiration Activity Monitoring System...

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Bibliographic Details
Main Authors: Nina Ihling, Lara Pauline Munkler, Christoph Berg, Britta Reichenbächer, Johannes Wirth, Dietmar Lang, Roland Wagner, Jochen Büchs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Chinese hamster ovary (CHO cells)
mass transfer characteristics
shake flask cultivation
oxygen transfer rate
time-resolved monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.725498/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.725498/full

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