Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ-induced chromosomal instability and apoptosis sensitivity

Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ-induced chromosomal instability and apoptosis sensitivity

Pleiotropic pro-inflammatory cytokines, TNF-α and IFN-γ (TI), play important yet diverse roles in cell survival, proliferation, and death. Recent evidence highlights FAT10 as a downstream molecule in the pathway of inflammation-induced tumorigenesis through mediating the effect of cytokines in causi...

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Bibliographic Details
Main Authors: Yun Gao, Steven Setiawan Theng, Way-Champ Mah, Caroline G. L. Lee
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Biology Open
Subjects:
FAT10
Silibinin
TNF-α
IFN-γ
Chromosomal instability
Apoptosis
Online Access:http://bio.biologists.org/content/4/8/961

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