Bacterial internalization is required to trigger NIK-dependent NF-κB activation in response to the bacterial type three secretion system.

Bacterial internalization is required to trigger NIK-dependent NF-κB activation in response to the bacterial type three secretion system.

Infection of human cells with Yersinia pseudotuberculosis expressing a functional type III secretion system (T3SS) leads to activation of host NF-κB. We show that the Yersinia T3SS activates distinct NF-κB pathways dependent upon bacterial subcellular localization. We found that wildtype Yersinia ab...

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Bibliographic Details
Main Authors: Miles C Duncan, Natalia G Herrera, Kevin S Johnson, Joanne N Engel, Victoria Auerbuch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5293232?pdf=render

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