A Digital PCR-Based Method for Efficient and Highly Specific Screening of Genome Edited Cells.

A Digital PCR-Based Method for Efficient and Highly Specific Screening of Genome Edited Cells.

The rapid adoption of gene editing tools such as CRISPRs and TALENs for research and eventually therapeutics necessitates assays that can rapidly detect and quantitate the desired alterations. Currently, the most commonly used assay employs "mismatch nucleases" T7E1 or "Surveyor"...

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Bibliographic Details
Main Authors: Scott D Findlay, Krista M Vincent, Jennifer R Berman, Lynne-Marie Postovit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4835065?pdf=render

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