Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts

Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts

Renal fibrosis is the final common pathway of chronic kidney disease (CKD), and no effective medication is available clinically for managing its progression. Metformin was initially developed as an anti-diabetic drug and recently gained attention for its potential in the treatment of other diseases....

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Bibliographic Details
Main Authors: Yang Shen, Naijun Miao, Jinlan Xu, Xinxin Gan, Dan Xu, Li Zhou, Hong Xue, Wei Zhang, Limin Lu
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
metformin
renal fibrosis
ERK
angiotensin II
transforming growth factor-β
Online Access:http://www.mdpi.com/1422-0067/17/2/146

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