Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells

Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells

MicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if...

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Main Authors: Luis I. Terrazas, Fausto Sánchez-Muñoz, Magaly Pérez-Miranda, Ana M. Mejía-Domínguez, Yadira Ledesma-Soto, Rafael Bojalil, Lorena Gómez-García
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/972506
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spelling doaj-988dd47483eb44e587bbe28b719b425a2020-11-24T23:13:52ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/972506972506Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic CellsLuis I. Terrazas0Fausto Sánchez-Muñoz1Magaly Pérez-Miranda2Ana M. Mejía-Domínguez3Yadira Ledesma-Soto4Rafael Bojalil5Lorena Gómez-García6Biomedicine Unit, Facultad de Estudios Superiores Iztacala, UNAM, Avenida de los Barrios No. 1 Col. Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, MexicoBlood Bank, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, MexicoBiomedicine Unit, Facultad de Estudios Superiores Iztacala, UNAM, Avenida de los Barrios No. 1 Col. Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, MexicoDepartment of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1 Col. Sección XVI, 140080 Tlalpan, DF, MexicoMicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells. We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response. This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.http://dx.doi.org/10.1155/2013/972506
collection DOAJ
language English
format Article
sources DOAJ
author Luis I. Terrazas
Fausto Sánchez-Muñoz
Magaly Pérez-Miranda
Ana M. Mejía-Domínguez
Yadira Ledesma-Soto
Rafael Bojalil
Lorena Gómez-García
spellingShingle Luis I. Terrazas
Fausto Sánchez-Muñoz
Magaly Pérez-Miranda
Ana M. Mejía-Domínguez
Yadira Ledesma-Soto
Rafael Bojalil
Lorena Gómez-García
Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
BioMed Research International
author_facet Luis I. Terrazas
Fausto Sánchez-Muñoz
Magaly Pérez-Miranda
Ana M. Mejía-Domínguez
Yadira Ledesma-Soto
Rafael Bojalil
Lorena Gómez-García
author_sort Luis I. Terrazas
title Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
title_short Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
title_full Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
title_fullStr Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
title_full_unstemmed Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
title_sort helminth excreted/secreted antigens repress expression of lps-induced let-7i but not mir-146a and mir-155 in human dendritic cells
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description MicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells. We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response. This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.
url http://dx.doi.org/10.1155/2013/972506
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