Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

Summary: Inherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress conditions. Here, we report that GSCs depend on the adaptive activation of ER stress and subsequent activation of lipogenesis and particula...

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Main Authors: Kelsey Pinkham, David Jaehyun Park, Arsalan Hashemiaghdam, Aleksandar B. Kirov, Isam Adam, Kamila Rosiak, Cintia C. da Hora, Jian Teng, Pike See Cheah, Litia Carvalho, Gitali Ganguli-Indra, Avalon Kelly, Arup K. Indra, Christian E. Badr
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119300839

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