Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture.

Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture.

The conflicting results of recent pre-exposure prophylaxis (PrEP) trials utilizing tenofovir (TFV) to prevent HIV infection in women led us to evaluate the accumulation of intracellular TFV-diphosphate (TFV-DP) in cells from the female reproductive tract (FRT) and whether sex hormones influence the...

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Bibliographic Details
Main Authors: Zheng Shen, John V Fahey, Jack E Bodwell, Marta Rodriguez-Garcia, Angela D M Kashuba, Charles R Wira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4076265?pdf=render

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