Alkylated Sesamol Derivatives as Potent Antioxidants

• Main Authors: Ivanete C. Palheta, Lanalice R. Ferreira, Joyce K. L. Vale, Osmarina P. P. Silva, Anderson M. Herculano, Karen R. H. M. Oliveira, Antonio M. J. Chaves Neto, Joaquín M. Campos, Cleydson B. R. Santos, Rosivaldo S. Borges
• Format: Article
• Language: English
• Published: MDPI AG 2020-07-01
• Series: Molecules
• Subjects: antioxidant capacity; sesamol; DFT; electron transfer; hydrogen transfer
• Online Access: https://www.mdpi.com/1420-3049/25/14/3300

Sesamol is a phenolic derivative. Its antioxidant activity is low than that of Trolox and depends on benzodioxole moiety. Thus, a molecular modification strategy through alkylation, inspired by natural and synthetic antioxidants, was studied by molecular modeling at the DFT/B3LYP level of theory by comparing the 6-31+G(d,p) and 6-311++G(2d,2p) basis sets. All proposed derivatives were compared to classical related antioxidants such as Trolox, <i>t</i>-butylated hydroxytoluene (BHT) and <i>t</i>-butylated hydroxyanisole (BHA). According to our results, molecular orbitals, single electron or hydrogen-atom transfers, spin density distributions, and alkyl substitutions at the ortho positions related to phenol moiety were found to be more effective than any other positions. The trimethylated derivative was more potent than Trolox. <i>t</i>-Butylated derivatives were stronger than all other alkylated derivatives and may be new alternative forms of modified antioxidants from natural products with applications in the chemical, pharmaceutical, and food industries.