Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics

Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics

Depression, one of the most prevalent psychiatric diseases, affects the quality of life of millions of people. Studies have shown that the lower polar fraction of Bupleuri Radix (PBR) elicited therapeutic effects in chronic unpredictable mild stress (CUMS) rats. In contrast, comparatively mild liver...

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Bibliographic Details
Main Authors: Peng Wang, Xiaoxia Gao, Meili Liang, Yuan Fang, Jinping Jia, Junsheng Tian, Zhenyu Li, Xuemei Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
bupleuri radix
anti-depression
dose- effect/toxicity
UHPLC-MS
CUMS
liver metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.627451/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.627451/full

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