Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells.

Cancer can be envisioned as a metabolic disease driven by pressure selection and intercellular cooperativeness. Together with anaerobic glycolysis, the Warburg effect, formally corresponding to uncoupling glycolysis from oxidative phosphorylation, directly participates in cancer aggressiveness, supp...

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Bibliographic Details
Main Authors: Christophe J De Saedeleer, Tamara Copetti, Paolo E Porporato, Julien Verrax, Olivier Feron, Pierre Sonveaux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082126/pdf/?tool=EBI

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