PD-L1 monoclonal antibody-decorated nanoliposomes loaded with Paclitaxel and P-gp transport inhibitor for the synergistic chemotherapy against multidrug resistant gastric cancers

PD-L1 monoclonal antibody-decorated nanoliposomes loaded with Paclitaxel and P-gp transport inhibitor for the synergistic chemotherapy against multidrug resistant gastric cancers

Abstract Multidrug resistance (MDR) based on ATP-dependent efflux transporters (p-glycoprotein (p-gp)) remains a major obstacle in successful chemotherapy treatment. Herein, we have investigated the potential of PD-L1 mAb-conjugated nanoliposome to serve as a targeted delivery platform for the co-de...

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Bibliographic Details
Main Authors: Jinling Yu, Fengli Hu, Qiankun Zhu, Xiaodong Li, Haiyang Ren, Shengjie Fan, Bo Qian, Bo Zhai, Dongdong Yang
Format: Article
Language:English
Published: SpringerOpen 2020-03-01
Series:Nanoscale Research Letters
Subjects:
Multidrug resistance (MDR)
Paclitaxel
Tariquidar
Gastric cancer
Nanoliposomes
Online Access:http://link.springer.com/article/10.1186/s11671-019-3228-z

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http://link.springer.com/article/10.1186/s11671-019-3228-z

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