FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation

Fibrinogen-like protein 2 (FGL2) mediates immune suppression in glioblastoma (GBM). Here, the authors show that FGL-2 expressed by GBM cancer cells acts by suppressing the differentiation of CD103+ DC cells required to activate the anti-tumor CD8+ T cell response via blocking GM-CSF signalling at NF...

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Main Authors:	Jun Yan, Qingnan Zhao, Konrad Gabrusiewicz, Ling-Yuan Kong, Xueqing Xia, Jian Wang, Martina Ott, Jingda Xu, R. Eric Davis, Longfei Huo, Ganesh Rao, Shao-Cong Sun, Stephanie S. Watowich, Amy B. Heimberger, Shulin Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-08271-x

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spelling	doaj-985213d99a3d4bd49592495ca3e988402021-05-11T12:40:32ZengNature Publishing GroupNature Communications2041-17232019-01-0110111510.1038/s41467-018-08271-xFGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiationJun Yan0Qingnan Zhao1Konrad Gabrusiewicz2Ling-Yuan Kong3Xueqing Xia4Jian Wang5Martina Ott6Jingda Xu7R. Eric Davis8Longfei Huo9Ganesh Rao10Shao-Cong Sun11Stephanie S. Watowich12Amy B. Heimberger13Shulin Li14Center for Brain Disorders Research, Capital Medical UniversityDepartment of Pediatrics–Research, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Pediatrics–Research, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer CenterDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer CenterDepartment of Pediatrics–Research, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Immunology, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Pediatrics–Research, The University of Texas MD Anderson Cancer CenterFibrinogen-like protein 2 (FGL2) mediates immune suppression in glioblastoma (GBM). Here, the authors show that FGL-2 expressed by GBM cancer cells acts by suppressing the differentiation of CD103+ DC cells required to activate the anti-tumor CD8+ T cell response via blocking GM-CSF signalling at NFKB, STAT1/5 and p38 level.https://doi.org/10.1038/s41467-018-08271-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jun Yan Qingnan Zhao Konrad Gabrusiewicz Ling-Yuan Kong Xueqing Xia Jian Wang Martina Ott Jingda Xu R. Eric Davis Longfei Huo Ganesh Rao Shao-Cong Sun Stephanie S. Watowich Amy B. Heimberger Shulin Li
spellingShingle	Jun Yan Qingnan Zhao Konrad Gabrusiewicz Ling-Yuan Kong Xueqing Xia Jian Wang Martina Ott Jingda Xu R. Eric Davis Longfei Huo Ganesh Rao Shao-Cong Sun Stephanie S. Watowich Amy B. Heimberger Shulin Li FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation Nature Communications
author_facet	Jun Yan Qingnan Zhao Konrad Gabrusiewicz Ling-Yuan Kong Xueqing Xia Jian Wang Martina Ott Jingda Xu R. Eric Davis Longfei Huo Ganesh Rao Shao-Cong Sun Stephanie S. Watowich Amy B. Heimberger Shulin Li
author_sort	Jun Yan
title	FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
title_short	FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
title_full	FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
title_fullStr	FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
title_full_unstemmed	FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
title_sort	fgl2 promotes tumor progression in the cns by suppressing cd103+ dendritic cell differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Fibrinogen-like protein 2 (FGL2) mediates immune suppression in glioblastoma (GBM). Here, the authors show that FGL-2 expressed by GBM cancer cells acts by suppressing the differentiation of CD103+ DC cells required to activate the anti-tumor CD8+ T cell response via blocking GM-CSF signalling at NFKB, STAT1/5 and p38 level.
url	https://doi.org/10.1038/s41467-018-08271-x
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FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation

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