Structural and Functional Analysis of the Cdk13/Cyclin K Complex

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

Cyclin-dependent kinases regulate the cell cycle and transcription in higher eukaryotes. We have determined the crystal structure of the transcription kinase Cdk13 and its Cyclin K subunit at 2.0 Å resolution. Cdk13 contains a C-terminal extension helix composed of a polybasic cluster and a DCHEL mo...

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Bibliographic Details
Main Authors: Ann Katrin Greifenberg, Dana Hönig, Kveta Pilarova, Robert Düster, Koen Bartholomeeusen, Christian A. Bösken, Kanchan Anand, Dalibor Blazek, Matthias Geyer
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
transcription
Cdk13
Cyclin K
Pin1
RNA polymerase II
flavopiridolIntroduction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014382

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