Cut the noise or couple up: Coordinating circadian and synthetic clocks

Summary: Circadian clocks are important to much of life on Earth and are of inherent interest to humanity, implicated in fields ranging from agriculture and ecology to developmental biology and medicine. New techniques show that it is not simply the presence of clocks, but coordination between them...

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Main Authors:	Chris N. Micklem, James C.W. Locke
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Series:	iScience
Subjects:	Biological sciences Physiology Developmental biology Chronobiology Biophysics Mathematical biosciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221010191

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spelling	doaj-9842e94659b64859ad8c2cca276e1bfc2021-09-25T05:10:30ZengElsevieriScience2589-00422021-09-01249103051Cut the noise or couple up: Coordinating circadian and synthetic clocksChris N. Micklem0James C.W. Locke1The Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK; The Cavendish Laboratory, Department of Physics, University of Cambridge, JJ Thomson Avenue, Cambridge CH3 0HE, UKThe Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK; Corresponding authorSummary: Circadian clocks are important to much of life on Earth and are of inherent interest to humanity, implicated in fields ranging from agriculture and ecology to developmental biology and medicine. New techniques show that it is not simply the presence of clocks, but coordination between them that is critical for complex physiological processes across the kingdoms of life. Recent years have also seen impressive advances in synthetic biology to the point where parallels can be drawn between synthetic biological and circadian oscillators. This review will emphasize theoretical and experimental studies that have revealed a fascinating dichotomy of coupling and heterogeneity among circadian clocks. We will also consolidate the fields of chronobiology and synthetic biology, discussing key design principles of their respective oscillators.http://www.sciencedirect.com/science/article/pii/S2589004221010191Biological sciencesPhysiologyDevelopmental biologyChronobiologyBiophysicsMathematical biosciences
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chris N. Micklem James C.W. Locke
spellingShingle	Chris N. Micklem James C.W. Locke Cut the noise or couple up: Coordinating circadian and synthetic clocks iScience Biological sciences Physiology Developmental biology Chronobiology Biophysics Mathematical biosciences
author_facet	Chris N. Micklem James C.W. Locke
author_sort	Chris N. Micklem
title	Cut the noise or couple up: Coordinating circadian and synthetic clocks
title_short	Cut the noise or couple up: Coordinating circadian and synthetic clocks
title_full	Cut the noise or couple up: Coordinating circadian and synthetic clocks
title_fullStr	Cut the noise or couple up: Coordinating circadian and synthetic clocks
title_full_unstemmed	Cut the noise or couple up: Coordinating circadian and synthetic clocks
title_sort	cut the noise or couple up: coordinating circadian and synthetic clocks
publisher	Elsevier
series	iScience
issn	2589-0042
publishDate	2021-09-01
description	Summary: Circadian clocks are important to much of life on Earth and are of inherent interest to humanity, implicated in fields ranging from agriculture and ecology to developmental biology and medicine. New techniques show that it is not simply the presence of clocks, but coordination between them that is critical for complex physiological processes across the kingdoms of life. Recent years have also seen impressive advances in synthetic biology to the point where parallels can be drawn between synthetic biological and circadian oscillators. This review will emphasize theoretical and experimental studies that have revealed a fascinating dichotomy of coupling and heterogeneity among circadian clocks. We will also consolidate the fields of chronobiology and synthetic biology, discussing key design principles of their respective oscillators.
topic	Biological sciences Physiology Developmental biology Chronobiology Biophysics Mathematical biosciences
url	http://www.sciencedirect.com/science/article/pii/S2589004221010191
work_keys_str_mv	AT chrisnmicklem cutthenoiseorcoupleupcoordinatingcircadianandsyntheticclocks AT jamescwlocke cutthenoiseorcoupleupcoordinatingcircadianandsyntheticclocks
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Cut the noise or couple up: Coordinating circadian and synthetic clocks

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