Preventing and treating PTSD-like memory by trauma contextualization

Preventing and treating PTSD-like memory by trauma contextualization

Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues elim...

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Main Authors: Alice Shaam Al Abed, Eva-Gunnel Ducourneau, Chloé Bouarab, Azza Sellami, Aline Marighetto, Aline Desmedt
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18002-w
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spelling doaj-9837c4635cbe4367969ea714515e0a562021-08-29T11:40:05ZengNature Publishing GroupNature Communications2041-17232020-08-011111910.1038/s41467-020-18002-wPreventing and treating PTSD-like memory by trauma contextualizationAlice Shaam Al Abed0Eva-Gunnel Ducourneau1Chloé Bouarab2Azza Sellami3Aline Marighetto4Aline Desmedt5Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMNeurocentre Magendie, Physiopathologie de la plasticité neuronale, U1215, INSERMIndividuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.https://doi.org/10.1038/s41467-020-18002-w
collection DOAJ
language English
format Article
sources DOAJ
author Alice Shaam Al Abed
Eva-Gunnel Ducourneau
Chloé Bouarab
Azza Sellami
Aline Marighetto
Aline Desmedt
spellingShingle Alice Shaam Al Abed
Eva-Gunnel Ducourneau
Chloé Bouarab
Azza Sellami
Aline Marighetto
Aline Desmedt
Preventing and treating PTSD-like memory by trauma contextualization
Nature Communications
author_facet Alice Shaam Al Abed
Eva-Gunnel Ducourneau
Chloé Bouarab
Azza Sellami
Aline Marighetto
Aline Desmedt
author_sort Alice Shaam Al Abed
title Preventing and treating PTSD-like memory by trauma contextualization
title_short Preventing and treating PTSD-like memory by trauma contextualization
title_full Preventing and treating PTSD-like memory by trauma contextualization
title_fullStr Preventing and treating PTSD-like memory by trauma contextualization
title_full_unstemmed Preventing and treating PTSD-like memory by trauma contextualization
title_sort preventing and treating ptsd-like memory by trauma contextualization
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description Individuals with PTSD are unable to recollect contextual cues related to the trauma. Here the authors show that this contextual amnesia, associated with the inhibition of hippocampal activity, is causally involved in PTSD-like hypermnesia in mice, and that re-exposure to all trauma-related cues eliminates PTSD-like memory while promoting normal fear memory.
url https://doi.org/10.1038/s41467-020-18002-w
work_keys_str_mv AT aliceshaamalabed preventingandtreatingptsdlikememorybytraumacontextualization
AT evagunnelducourneau preventingandtreatingptsdlikememorybytraumacontextualization
AT chloebouarab preventingandtreatingptsdlikememorybytraumacontextualization
AT azzasellami preventingandtreatingptsdlikememorybytraumacontextualization
AT alinemarighetto preventingandtreatingptsdlikememorybytraumacontextualization
AT alinedesmedt preventingandtreatingptsdlikememorybytraumacontextualization
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