Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction

Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction

Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a difficult disease with high morbidity and mortality rates and lacks an effective treatment. Here, we report the therapeutic effect of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor (SGLT2i), on hypertension + ...

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Bibliographic Details
Main Authors: Nannan Zhang, Bin Feng, Xuexing Ma, Kangyun Sun, Guidong Xu, Yafeng Zhou
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cardiovascular Diabetology
Subjects:
SGLT2 inhibitor
Dapagliflozin
Hypertention
Heart failure with preserved ejection fraction
NO-cGMP-PKG pathway
Online Access:http://link.springer.com/article/10.1186/s12933-019-0914-1

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