In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity

The mitogen activated protein kinase p38 plays a role in the receptor activator of NF-ĸB ligand (RANKL)-induced osteoclast differentiation. In this study, we investigated the effect of p38 inhibitor doramapimod on the osteoclast differentiation. Doramapimod significantly inhibited the osteoclastogen...

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Bibliographic Details
Main Authors: Seong-Hee Moon, Sik-Won Choi, Seong Hwan Kim
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Doramapimod
p38 inhibitor
Osteoclast differentiation
Migration
Fusion
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315001206

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http://www.sciencedirect.com/science/article/pii/S1347861315001206

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