A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer

Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) that mediate T-cell immune responses. Breast cancer is one of the most commonly diagnosed diseases and its mortality rate is higher than any other cancer in both humans and canines. Plantain polysaccharide (PLP),...

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Main Authors:	Jiafeng Gao, Yi-Nan Zhang, Jingwen Cui, Jiatong Zhang, Yuexiang Ming, Zhihui Hao, Huihao Xu, Nan Cheng, Di Zhang, Yipeng Jin, Degui Lin, Jiahao Lin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Pharmacology
Subjects:	Plantago asiatica L dendritic cells cytotoxic T cells breast tumor immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.678865/full

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spelling	doaj-983139cc0f6d4d5fa4ad8cb4a02177a22021-08-24T10:14:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-08-011210.3389/fphar.2021.678865678865A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast CancerJiafeng Gao0Yi-Nan Zhang1Jingwen Cui2Jiatong Zhang3Yuexiang Ming4Zhihui Hao5Zhihui Hao6Huihao Xu7Nan Cheng8Di Zhang9Yipeng Jin10Degui Lin11Jiahao Lin12Jiahao Lin13The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaInstitute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Toronto, CanadaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaCenter of Research and Innovation of Chinese Traditional Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaCenter of Research and Innovation of Chinese Traditional Veterinary Medicine, China Agricultural University, Beijing, ChinaDendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) that mediate T-cell immune responses. Breast cancer is one of the most commonly diagnosed diseases and its mortality rate is higher than any other cancer in both humans and canines. Plantain polysaccharide (PLP), extracted from the whole plant of Plantago asiatica L., could promote the maturation of DCs. In this research, we found that PLP could upregulate the maturation of DCs both in vitro and in vivo. PLP-activated DCs could stimulate lymphocytes’ proliferation and differentiate naive T cells into cytotoxic T cells. Tumor antigen-specific lymphocyte responses were enhanced by PLP and CIPp canine breast tumor cells lysate-pulsed DCs, and PLP and CIPp-cell-lysate jointly stimulated DCs cocultured with lymphocytes having the great cytotoxicity on CIPp cells. In the 4T1 murine breast tumor model, PLP could control the size of breast tumors and improve immunity by recruiting DCs, macrophages, and CD4+ and CD8+ T cells in the tumor microenvironment. These results indicated that PLP could achieve immunotherapeutic effects and improve immunity in the breast tumor model.https://www.frontiersin.org/articles/10.3389/fphar.2021.678865/fullPlantago asiatica Ldendritic cellscytotoxic T cellsbreast tumorimmunotherapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiafeng Gao Yi-Nan Zhang Jingwen Cui Jiatong Zhang Yuexiang Ming Zhihui Hao Zhihui Hao Huihao Xu Nan Cheng Di Zhang Yipeng Jin Degui Lin Jiahao Lin Jiahao Lin
spellingShingle	Jiafeng Gao Yi-Nan Zhang Jingwen Cui Jiatong Zhang Yuexiang Ming Zhihui Hao Zhihui Hao Huihao Xu Nan Cheng Di Zhang Yipeng Jin Degui Lin Jiahao Lin Jiahao Lin A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer Frontiers in Pharmacology Plantago asiatica L dendritic cells cytotoxic T cells breast tumor immunotherapy
author_facet	Jiafeng Gao Yi-Nan Zhang Jingwen Cui Jiatong Zhang Yuexiang Ming Zhihui Hao Zhihui Hao Huihao Xu Nan Cheng Di Zhang Yipeng Jin Degui Lin Jiahao Lin Jiahao Lin
author_sort	Jiafeng Gao
title	A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer
title_short	A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer
title_full	A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer
title_fullStr	A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer
title_full_unstemmed	A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer
title_sort	polysaccharide from the whole plant of plantago asiatica l. enhances the antitumor activity of dendritic cell-based immunotherapy against breast cancer
publisher	Frontiers Media S.A.
series	Frontiers in Pharmacology
issn	1663-9812
publishDate	2021-08-01
description	Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) that mediate T-cell immune responses. Breast cancer is one of the most commonly diagnosed diseases and its mortality rate is higher than any other cancer in both humans and canines. Plantain polysaccharide (PLP), extracted from the whole plant of Plantago asiatica L., could promote the maturation of DCs. In this research, we found that PLP could upregulate the maturation of DCs both in vitro and in vivo. PLP-activated DCs could stimulate lymphocytes’ proliferation and differentiate naive T cells into cytotoxic T cells. Tumor antigen-specific lymphocyte responses were enhanced by PLP and CIPp canine breast tumor cells lysate-pulsed DCs, and PLP and CIPp-cell-lysate jointly stimulated DCs cocultured with lymphocytes having the great cytotoxicity on CIPp cells. In the 4T1 murine breast tumor model, PLP could control the size of breast tumors and improve immunity by recruiting DCs, macrophages, and CD4+ and CD8+ T cells in the tumor microenvironment. These results indicated that PLP could achieve immunotherapeutic effects and improve immunity in the breast tumor model.
topic	Plantago asiatica L dendritic cells cytotoxic T cells breast tumor immunotherapy
url	https://www.frontiersin.org/articles/10.3389/fphar.2021.678865/full
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A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer

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