Association between <i>VDR</i> polymorphism and multiple sclerosis

• Main Authors: S. A. Babenko, V. M. Alifirova, Yu. Yu. Orlova, V. P. Pusyryov
• Format: Article
• Language: English
• Published: Siberian State Medical University (Tomsk) 2008-12-01
• Series: Bûlleten' Sibirskoj Mediciny
• Online Access: https://bulletin.tomsk.ru/jour/article/view/3435

Genotypes and haplotypes frequencies for VDR polymorphisms in case-control studies of multiple sclerosis (MS) were investigated. Results show an association of VDR T/t variant with diseases (p &lt; 0,05). This marker was also associated with amount of eosinophils in MS patients (p &lt; 0,05). Polymorphisms B/b and F/f was associated with ESR level, IgG level and amount of the CD16+ cell (p &lt; 0,05). We demonstrate that the Bft haplotype significantly higher observed at MS patients and btT — at healthy person Received data allow suggests that the allele t VDR and Bft haplotype of VDR gene could increase susceptibility to MS and have influence on clinical manifestation of diseases.