Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist S6 Stimulates Insulin Secretion From Rat Islets

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist S6 Stimulates Insulin Secretion From Rat Islets

Glucagon-like peptide-1 receptor (GLP-1R) agonist-based therapeutics for type 2 diabetes mellitus have attracted worldwide attention. However, there are challenges in the development of small molecule GLP-1R agonists owing to the complexity of ligand recognition and signal induction mechanisms. Here...

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Bibliographic Details
Main Authors:	Xiaohua Yang, Min Zhang, Zhihong Lu, Linping Zhi, Huan Xue, Tao Liu, Mengmeng Liu, Lijuan Cui, Zhihong Liu, Peifeng He, Yunfeng Liu, Yi Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Pharmacology
Subjects:	virtual screening insulin secretion glucagon-like peptide-1 receptor (GLP-1R) intracellular calcium concentration [(Ca2+)i] voltage-dependent K+ (Kv) channel
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.664802/full

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