Single chain variable fragment against aβ expressed in baculovirus inhibits abeta fibril elongation and promotes its disaggregation.

Single chain variable fragment against aβ expressed in baculovirus inhibits abeta fibril elongation and promotes its disaggregation.

Alzheimer's disease (AD) is the most common form of age-related dementia, and the most urgent problem is that it is currently incurable. Amyloid-β (Aβ) peptide is believed to play a major role in the pathogenesis of AD. We previously reported that an Aβ N-terminal amino acid targeting monoclona...

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Bibliographic Details
Main Authors: Ying Zhang, Hai-Qiang Yang, Fang Fang, Lin-Lin Song, Yue-Ying Jiao, He Wang, Xiang-Lei Peng, Yan-Peng Zheng, Jun Wang, Jin-Sheng He, Tao Hung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4412524?pdf=render

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http://europepmc.org/articles/PMC4412524?pdf=render

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