Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11000 |
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doaj-982278f7c02745b09c2db25ee3867b432021-05-11T10:34:55ZengNature Publishing GroupNature Communications2041-17232016-03-017111110.1038/ncomms11000Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureusQuanjiang Ji0Peter J. Chen1Guangrong Qin2Xin Deng3Ziyang Hao4Zdzislaw Wawrzak5Won-Sik Yeo6Jenny Winjing Quang7Hoonsik Cho8Guan-Zheng Luo9Xiaocheng Weng10Qiancheng You11Chi-Hao Luan12Xiaojing Yang13Taeok Bae14Kunqian Yu15Hualiang Jiang16Chuan He17Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoState Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoSynchrotron Research Center, LS-CAT, Northwestern UniversityIndiana University School of Medicine-NorthwestDepartment of Molecular Biosciences, High-Throughput Analysis Laboratory, Center for Structural Genomics of Infectious Diseases, Northwestern UniversityIndiana University School of Medicine-NorthwestDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoDepartment of Molecular Biosciences, High-Throughput Analysis Laboratory, Center for Structural Genomics of Infectious Diseases, Northwestern UniversityDepartment of Biochemistry and Molecular Biology, University of ChicagoIndiana University School of Medicine-NorthwestState Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of SciencesState Key Laboratory of Drug Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of SciencesDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of ChicagoThe WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator.https://doi.org/10.1038/ncomms11000 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He |
| spellingShingle |
Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus Nature Communications |
| author_facet |
Quanjiang Ji Peter J. Chen Guangrong Qin Xin Deng Ziyang Hao Zdzislaw Wawrzak Won-Sik Yeo Jenny Winjing Quang Hoonsik Cho Guan-Zheng Luo Xiaocheng Weng Qiancheng You Chi-Hao Luan Xiaojing Yang Taeok Bae Kunqian Yu Hualiang Jiang Chuan He |
| author_sort |
Quanjiang Ji |
| title |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_short |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_full |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_fullStr |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_full_unstemmed |
Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus |
| title_sort |
structure and mechanism of the essential two-component signal-transduction system walkr in staphylococcus aureus |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
The WalKR signal transduction system is involved in extracellular signal recognition, but the details of this function are not well established. Here, the authors report the crystal structure of this two-component system alongside the characterisation of a small-molecule activator. |
| url |
https://doi.org/10.1038/ncomms11000 |
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