Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of disorders, in particular major depression and neuropathic pain. In the 1970s the ability of tricyclic antidepressants to inhibit acid sphingomyelinase (ASM) was discovered. The enzyme ASM catalyzes the hydrol...

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Bibliographic Details
Main Authors: Nadine eBeckmann, Deepa eSharma, Erich eGulbins, Katrin Anne Becker, Bärbel eEdelmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Physiology
Subjects:
Amitriptyline
signaling
Antidepressants
ceramide
acid sphingomyelinase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00331/full

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