Botulinum Toxin Suppression of CNS Network Activity In Vitro

The botulinum toxins are potent agents which disrupt synaptic transmission. While the standard method for BoNT detection and quantification is based on the mouse lethality assay, we have examined whether alterations in cultured neuronal network activity can be used to detect the functional effects o...

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Bibliographic Details
Main Authors: Joseph J. Pancrazio, Kamakshi Gopal, Edward W. Keefer, Guenter W. Gross
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2014/732913