INFLUENCES OF THIAMINE AND/OR ASCORBIC ACID ON LEAD INTOXICATION

• Main Authors: M. Ghazi-Khansari, A. Hajighasemkhan, S. Ghazaie
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 1996-12-01
• Series: Acta Medica Iranica
• Online Access: https://acta.tums.ac.ir/index.php/acta/article/view/1695

The effects of thiamine, ascorbic acid ami their combination an workers who are continuously exposal to lead has been investigated. In this study 60 persons in a Battery industry was selected and divided into four equal groups. Group I received placebo, group II thiamine (300 mg), group III ascorbic acid (250 mg) anil group IV thiamine (300 mg) plus ascorbic acid (250 mg) three times a day (Orally). At beginning of the study and after one month of above drug regimen; blood, urine and a questionnaire about their clinical signs were examined. 'there were no significant differences between blood anil urine lead level in all groups after treatment. Zinc protoporphyrin (zpp) level showed a significant reduction in ascorbic acid treated group (group III) as compared to pretreatment. Clinical manifestation improved in the group that received both vitamins (group IV). However, from a clinical stand point, it appears the usage of these vitamins may have a beneficial effects in lead occupational exposure.