Oncogenic functions of hMDMX in <it>in vitro </it>transformation of primary human fibroblasts and embryonic retinoblasts

Oncogenic functions of hMDMX in <it>in vitro </it>transformation of primary human fibroblasts and embryonic retinoblasts

<p>Abstract</p> <p>Background</p> <p>In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53 protein is functionally impaired. The two main inhibitors of p53, hMDM2 (MDM2) and hMDMX (...

Full description

Bibliographic Details
Main Authors: van der Burg Marja JM, Wiercinska Eliza, Verlaan-de Vries Matty, Lodder Kirsten, Teunisse Amina FAS, de Lange Job, Lenos Kristiaan, Szuhai Karoly, Jochemsen Aart G
Format: Article
Language:English
Published: BMC 2011-09-01
Series:Molecular Cancer
Subjects:
Transformation model
p53 pathway
tumorigenesis
hMDMX
hMDM2
retinoblastoma
Nutlin-3
Online Access:http://www.molecular-cancer.com/content/10/1/111

Similar Items

Similar Items