Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro

Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro

Laminins are one of the major protein groups in the extracellular matrix (ECM) and specific laminin isoforms are crucial for neuronal functions in the central nervous system in vivo. In the present study, we compared recombinant human laminin isoforms (LN211, LN332, LN411, LN511, and LN521) and lami...

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Bibliographic Details
Main Authors: Anu Hyysalo, Mervi Ristola, Meeri E.-L. Mäkinen, Sergei Häyrynen, Matti Nykter, Susanna Narkilahti
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Research
Subjects:
Alpha5 laminin substrate
Human pluripotent stem cell-derived neuron
In vitro culturing
Microelectrode array
Neuronal networks
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117301873

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