Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma

Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma

A 27-year-old male patient presented with speech disorders and multiple brain masses on MRI evaluation. He tested positive for HIV. A sterotactic biopsy diagnosed primary central nervous system lymphoma (diffuse large B-cell lymphoma). After two cycles of high-dose metotrexate (HD-MTX-)-based chemot...

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Main Authors: Hugo Ferro, Eduardo Parino
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2012/343491
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spelling doaj-97f5942c6b294bb6babcae038077d6b22020-11-24T22:39:22ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142012-01-01201210.1155/2012/343491343491Salvage Therapy for Refractory Aids-Related Primary Central Nervous System LymphomaHugo Ferro0Eduardo Parino1Department of Internal Medicine, Clínica y Maternidad Suizo, Argentina, Avenida Pueyrredon 1461, C1118AAE Buenos Aires, ArgentinaDepartment of Internal Medicine, Clínica y Maternidad Suizo, Argentina, Avenida Pueyrredon 1461, C1118AAE Buenos Aires, ArgentinaA 27-year-old male patient presented with speech disorders and multiple brain masses on MRI evaluation. He tested positive for HIV. A sterotactic biopsy diagnosed primary central nervous system lymphoma (diffuse large B-cell lymphoma). After two cycles of high-dose metotrexate (HD-MTX-)-based chemotherapy, the tumor progressed. He underwent whole brain radiotherapy achieving complete response. Six cycles of consolidating immunochemotherapy with rituximab-temozolomide were administered after radiation. Forty-three months after remission, he has not recurred and his neurological status is optimal. Younger HIV patients with refractory PCNSL and preserved immune function can face salvage therapy successfully achieving long term remissions with no remarkable neurotoxicity.http://dx.doi.org/10.1155/2012/343491
collection DOAJ
language English
format Article
sources DOAJ
author Hugo Ferro
Eduardo Parino
spellingShingle Hugo Ferro
Eduardo Parino
Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
Case Reports in Oncological Medicine
author_facet Hugo Ferro
Eduardo Parino
author_sort Hugo Ferro
title Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
title_short Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
title_full Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
title_fullStr Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
title_full_unstemmed Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma
title_sort salvage therapy for refractory aids-related primary central nervous system lymphoma
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2012-01-01
description A 27-year-old male patient presented with speech disorders and multiple brain masses on MRI evaluation. He tested positive for HIV. A sterotactic biopsy diagnosed primary central nervous system lymphoma (diffuse large B-cell lymphoma). After two cycles of high-dose metotrexate (HD-MTX-)-based chemotherapy, the tumor progressed. He underwent whole brain radiotherapy achieving complete response. Six cycles of consolidating immunochemotherapy with rituximab-temozolomide were administered after radiation. Forty-three months after remission, he has not recurred and his neurological status is optimal. Younger HIV patients with refractory PCNSL and preserved immune function can face salvage therapy successfully achieving long term remissions with no remarkable neurotoxicity.
url http://dx.doi.org/10.1155/2012/343491
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AT eduardoparino salvagetherapyforrefractoryaidsrelatedprimarycentralnervoussystemlymphoma
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