Poly (A) tail length of human mitochondrial mRNAs is tissue-specific and a mutation in LRPPRC results in transcript-specific patterns of deadenylation

Poly (A) tail length of human mitochondrial mRNAs is tissue-specific and a mutation in LRPPRC results in transcript-specific patterns of deadenylation

Mutations in LRPPRC cause Leigh Syndrome French Canadian (LSFC), an early onset neurodegenerative disease, with differential tissue involvement. The molecular basis for tissue specificity in this disease remains unknown. LRPPRC, an RNA binding protein, forms a stable complex with SLIRP, which binds...

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Bibliographic Details
Main Authors: Shamisa Honarmand, Eric A. Shoubridge
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
LRPPRC
RNA binding proteins
Leigh syndrome
Polyadenylation
Mitochondrial translation
Oxidative phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426920301336

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http://www.sciencedirect.com/science/article/pii/S2214426920301336

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