Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSC) promote tumor growth by blocking anti-tumor T cell responses. Recent reports show that MDSC increase fatty acid uptake and fatty acid oxidation (FAO) to support their immunosuppressive functions. Inhibition of FAO promoted a therapeutic T cell-mediated anti-tu...

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Bibliographic Details
Main Authors: Amir A. Al-Khami, Liqin Zheng, Luis Del Valle, Fokhrul Hossain, Dorota Wyczechowska, Jovanny Zabaleta, Maria D. Sanchez, Matthew J. Dean, Paulo C. Rodriguez, Augusto C. Ochoa
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
immunometabolism
immune suppression
lipids
mdsc
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1344804

Internet

http://dx.doi.org/10.1080/2162402X.2017.1344804

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