Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis.

Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis.

β-Catenin plays dual role in adhesion complex formation and the Wnt signaling pathway. Although β-catenin expression appears to be upregulated and Wnt signaling pathway is activated in the majority of cancers, its expression level seems to be lost in non-small cell lung cancer (NSCLC). We previously...

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Bibliographic Details
Main Authors: Yuan Miao, Liang Wang, Xiupeng Zhang, Xiaohan Xu, Guiyang Jiang, Chuifeng Fan, Yang Liu, Xuyong Lin, Juanhan Yu, Yong Zhang, Enhua Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4232381?pdf=render

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