Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity

Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity

Background: Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes. Meth...

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Bibliographic Details
Main Authors: Che-Hong Chen, Julio C.B. Ferreira, Amit U. Joshi, Matthew C. Stevens, Sin-Jin Li, Jade H.-M. Hsu, Rory Maclean, Nikolas D. Ferreira, Pilar R. Cervantes, Diana D. Martinez, Fernando L. Barrientos, Gibran H.R. Quintanares, Daria Mochly-Rosen
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:EBioMedicine
Subjects:
ALDH2 deficiency
Alda-1 and -64
Alcohol toxicity
Novel mutations
Health burden
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301286

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http://www.sciencedirect.com/science/article/pii/S2352396420301286

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