Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Information developed to understand the molecular mechanisms of SARS-CoV-2 infection for predicting drug repurposing candidates is time-consuming to integrate and explore. Here, the authors develop an interactive online platform for virus-host interactome exploration and drug (target) identification...

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Main Authors: Sepideh Sadegh, Julian Matschinske, David B. Blumenthal, Gihanna Galindez, Tim Kacprowski, Markus List, Reza Nasirigerdeh, Mhaned Oubounyt, Andreas Pichlmair, Tim Daniel Rose, Marisol Salgado-Albarrán, Julian Späth, Alexey Stukalov, Nina K. Wenke, Kevin Yuan, Josch K. Pauling, Jan Baumbach
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17189-2
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spelling doaj-97cfd30dcc8f444386de8cedd10dff722021-07-18T11:44:03ZengNature Publishing GroupNature Communications2041-17232020-07-011111910.1038/s41467-020-17189-2Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposingSepideh Sadegh0Julian Matschinske1David B. Blumenthal2Gihanna Galindez3Tim Kacprowski4Markus List5Reza Nasirigerdeh6Mhaned Oubounyt7Andreas Pichlmair8Tim Daniel Rose9Marisol Salgado-Albarrán10Julian Späth11Alexey Stukalov12Nina K. Wenke13Kevin Yuan14Josch K. Pauling15Jan Baumbach16Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichInstitute of Virology, TUM School of Medicine, Technical University of MunichLipiTUM, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichInstitute of Virology, TUM School of Medicine, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichLipiTUM, Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichChair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of MunichInformation developed to understand the molecular mechanisms of SARS-CoV-2 infection for predicting drug repurposing candidates is time-consuming to integrate and explore. Here, the authors develop an interactive online platform for virus-host interactome exploration and drug (target) identification.https://doi.org/10.1038/s41467-020-17189-2
collection DOAJ
language English
format Article
sources DOAJ
author Sepideh Sadegh
Julian Matschinske
David B. Blumenthal
Gihanna Galindez
Tim Kacprowski
Markus List
Reza Nasirigerdeh
Mhaned Oubounyt
Andreas Pichlmair
Tim Daniel Rose
Marisol Salgado-Albarrán
Julian Späth
Alexey Stukalov
Nina K. Wenke
Kevin Yuan
Josch K. Pauling
Jan Baumbach
spellingShingle Sepideh Sadegh
Julian Matschinske
David B. Blumenthal
Gihanna Galindez
Tim Kacprowski
Markus List
Reza Nasirigerdeh
Mhaned Oubounyt
Andreas Pichlmair
Tim Daniel Rose
Marisol Salgado-Albarrán
Julian Späth
Alexey Stukalov
Nina K. Wenke
Kevin Yuan
Josch K. Pauling
Jan Baumbach
Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
Nature Communications
author_facet Sepideh Sadegh
Julian Matschinske
David B. Blumenthal
Gihanna Galindez
Tim Kacprowski
Markus List
Reza Nasirigerdeh
Mhaned Oubounyt
Andreas Pichlmair
Tim Daniel Rose
Marisol Salgado-Albarrán
Julian Späth
Alexey Stukalov
Nina K. Wenke
Kevin Yuan
Josch K. Pauling
Jan Baumbach
author_sort Sepideh Sadegh
title Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
title_short Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
title_full Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
title_fullStr Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
title_full_unstemmed Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing
title_sort exploring the sars-cov-2 virus-host-drug interactome for drug repurposing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description Information developed to understand the molecular mechanisms of SARS-CoV-2 infection for predicting drug repurposing candidates is time-consuming to integrate and explore. Here, the authors develop an interactive online platform for virus-host interactome exploration and drug (target) identification.
url https://doi.org/10.1038/s41467-020-17189-2
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