DRUG INTERACTIONS OF NEW ORAL ANTICOAGULANTS: INSIDE AND OUTSIDE TABLE CELLS

• Main Authors: S. N. Bel'diev, I. V. Medvedeva, D. Yu. Platonov
• Format: Article
• Language: English
• Published: Stolichnaya Izdatelskaya Kompaniya 2017-11-01
• Series: Racionalʹnaâ Farmakoterapiâ v Kardiologii
• Subjects: dabigatran; apixaban; rivaroxaban; edoxaban; drug interactions
• Online Access: https://www.rpcardio.com/jour/article/view/1540

The opinion is expressed in some  domestic publications that  rivaroxaban has  the  most  favorable profile of drug  interaction in comparison with other new oral anticoagulants (NOAC). The basis for such judgments is the summary table of drug interaction from the Guidelines of the European Heart Rhythm Association 2015 on the use of NOAC in patients with non-valvular atrial fibrillation.The paper discusses the issue that the abovementioned table contains some incorrect qualitative statements and quantitative data inconsistent with primary source  of information of NOAC drug interactions, and provides the updated and extended information on changes in NOAC plasma concentrations when  co-administered with drugs from the other  groups. On the basis of the presented data, the authors come to the conclusion that the profile of drug interaction of rivaroxaban does not differ significantly from these  of the other NOAC.