Epitope mapping of M36, a human antibody domain with potent and broad HIV-1 inhibitory activity.

Epitope mapping of M36, a human antibody domain with potent and broad HIV-1 inhibitory activity.

M36 is the first member of a novel class of potent HIV-1 entry inhibitors based on human engineered antibody domains (eAds). It exhibits broad inhibitory activity suggesting that its CD4-induced epitope is highly conserved. Here, we describe fine mapping of its epitope by using several approaches. F...

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Bibliographic Details
Main Authors: Chao Wan, Jianping Sun, Weizao Chen, Xiaohui Yuan, Huihui Chong, Ponraj Prabakaran, Dimiter S Dimitrov, Yuxian He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3679054?pdf=render

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