Liposome and Their Applications in Cancer Therapy

• Main Authors: Himanshu Pandey, Radha Rani, Vishnu Agarwal
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Paraná (Tecpar) 2016-01-01
• Series: Brazilian Archives of Biology and Technology
• Subjects: Liposomes; Drug delivery; Cancer; Doxil; LipoDox; Myocet
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100303&lng=en&tlng=en

ABSTRACT Liposomes, the vesicles of phospholipid bilayer, can encapsulate both hydrophilic and lipophilic drugs and protect them from degradation. Liposomes have been extensively studied and continue to create intense interest in research since their discovery in the mid-1960s. Since then, liposomes have been considered to be the most successful nanocarriers for drug deliver and have made their way to the market. Currently, a number of liposomal formulations are on the marker for cancer treatment and many more are in pipe line. This review discusses about the liposome components, methods of preparation, drug encapsulation mechanism and the potential therapeutic applications of liposomes in cancer therapy.