An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting...

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Bibliographic Details
Main Authors:	Lihua Li, Yan Wang, Jun Chen, Bi Cheng, Jiehua Hu, Yuehua Zhou, Xin Gao, Liucun Gao, Xifan Mei, Meiyan Sun, Zhuomei Zhang, Haifeng Song
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2013/423129

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