An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting...

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Main Authors:	Lihua Li, Yan Wang, Jun Chen, Bi Cheng, Jiehua Hu, Yuehua Zhou, Xin Gao, Liucun Gao, Xifan Mei, Meiyan Sun, Zhuomei Zhang, Haifeng Song
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2013/423129

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spelling	doaj-979cffb75d754441992e827bd0b095082020-11-24T23:14:26ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/423129423129An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In VivoLihua Li0Yan Wang1Jun Chen2Bi Cheng3Jiehua Hu4Yuehua Zhou5Xin Gao6Liucun Gao7Xifan Mei8Meiyan Sun9Zhuomei Zhang10Haifeng Song11Department of Biology, Liaoning Medical University, Jinzhou 121001, ChinaInstitute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaDepartment of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaInstitute of Psychology, Chinese Academy of Sciences, Beijing 100101, ChinaEducational Technologies and Simulation Training Centre, Naval University of Engineering Tianjin Campus, Tianjin 300450, ChinaShanghai Junshi Biosciences Inc., Shanghai 201203, ChinaDepartment of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaDepartment of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaDepartment of Biology, Liaoning Medical University, Jinzhou 121001, ChinaCentral Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, ChinaDepartment of Gynecology and Obstetrics, General Hospital of Chinese Armed Police, Beijing 100039, ChinaDepartment of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing 100850, ChinaArginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.http://dx.doi.org/10.1155/2013/423129
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lihua Li Yan Wang Jun Chen Bi Cheng Jiehua Hu Yuehua Zhou Xin Gao Liucun Gao Xifan Mei Meiyan Sun Zhuomei Zhang Haifeng Song
spellingShingle	Lihua Li Yan Wang Jun Chen Bi Cheng Jiehua Hu Yuehua Zhou Xin Gao Liucun Gao Xifan Mei Meiyan Sun Zhuomei Zhang Haifeng Song An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo Evidence-Based Complementary and Alternative Medicine
author_facet	Lihua Li Yan Wang Jun Chen Bi Cheng Jiehua Hu Yuehua Zhou Xin Gao Liucun Gao Xifan Mei Meiyan Sun Zhuomei Zhang Haifeng Song
author_sort	Lihua Li
title	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
title_short	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
title_full	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
title_fullStr	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
title_full_unstemmed	An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo
title_sort	engineered arginase fc protein inhibits tumor growth in vitro and in vivo
publisher	Hindawi Limited
series	Evidence-Based Complementary and Alternative Medicine
issn	1741-427X 1741-4288
publishDate	2013-01-01
description	Arginine is a semiessential amino acid required for the growth of melanoma and hepatocellular carcinoma, and the enzymatic removal of arginine by pegylated arginine deiminase (ADI) or arginase is being tested clinically. Here, we report a genetically engineered arginase FC fusion protein exhibiting a prolonged half-life and enhanced efficacy. The use of this enzyme to treat different tumor lines both inhibited cell proliferation and impaired cellular migration in vitro and in vivo. Our data reinforce the hypothesis that nutritional depletion is a key strategy for cancer treatment.
url	http://dx.doi.org/10.1155/2013/423129
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An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

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