Capturing transient antibody conformations with DNA origami epitopes

Understanding antibody-antigen interactions is important to deepen the understanding of immunology. Here, the authors report on the application of DNA origami structures for the controlled presentation of antigens to study antibody binding behaviours at room temperature.

Bibliographic Details
Main Authors:	Ping Zhang, Xiaoguo Liu, Pi Liu, Fei Wang, Hirotaka Ariyama, Toshio Ando, Jianping Lin, Lihua Wang, Jun Hu, Bin Li, Chunhai Fan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16949-4

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spelling	doaj-9790c451ed904099bfb8bd0d6eb1ee6a2021-06-20T11:14:24ZengNature Publishing GroupNature Communications2041-17232020-06-011111910.1038/s41467-020-16949-4Capturing transient antibody conformations with DNA origami epitopesPing Zhang0Xiaoguo Liu1Pi Liu2Fei Wang3Hirotaka Ariyama4Toshio Ando5Jianping Lin6Lihua Wang7Jun Hu8Bin Li9Chunhai Fan10CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of SciencesSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational MedicineState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai UniversitySchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational MedicineNano Life Science Institute (WPI NanoLSI), Kanazawa UniversityNano Life Science Institute (WPI NanoLSI), Kanazawa UniversityState Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai UniversityShanghai Synchrotron Radiation Center, Shanghai Advanced Research Institute, Chinese Academy of SciencesCAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of SciencesCAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of SciencesSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Translational MedicineUnderstanding antibody-antigen interactions is important to deepen the understanding of immunology. Here, the authors report on the application of DNA origami structures for the controlled presentation of antigens to study antibody binding behaviours at room temperature.https://doi.org/10.1038/s41467-020-16949-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ping Zhang Xiaoguo Liu Pi Liu Fei Wang Hirotaka Ariyama Toshio Ando Jianping Lin Lihua Wang Jun Hu Bin Li Chunhai Fan
spellingShingle	Ping Zhang Xiaoguo Liu Pi Liu Fei Wang Hirotaka Ariyama Toshio Ando Jianping Lin Lihua Wang Jun Hu Bin Li Chunhai Fan Capturing transient antibody conformations with DNA origami epitopes Nature Communications
author_facet	Ping Zhang Xiaoguo Liu Pi Liu Fei Wang Hirotaka Ariyama Toshio Ando Jianping Lin Lihua Wang Jun Hu Bin Li Chunhai Fan
author_sort	Ping Zhang
title	Capturing transient antibody conformations with DNA origami epitopes
title_short	Capturing transient antibody conformations with DNA origami epitopes
title_full	Capturing transient antibody conformations with DNA origami epitopes
title_fullStr	Capturing transient antibody conformations with DNA origami epitopes
title_full_unstemmed	Capturing transient antibody conformations with DNA origami epitopes
title_sort	capturing transient antibody conformations with dna origami epitopes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Understanding antibody-antigen interactions is important to deepen the understanding of immunology. Here, the authors report on the application of DNA origami structures for the controlled presentation of antigens to study antibody binding behaviours at room temperature.
url	https://doi.org/10.1038/s41467-020-16949-4
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Capturing transient antibody conformations with DNA origami epitopes

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